794 research outputs found
The relationship between SNPS in the genes of TLR signal transduction pathway downstream elements and rheumatoid arthritis susceptibility
Toll-like receptors (TLRs) play an important role in the induction and regulation of the innate immune system or adaptive immune responses. Genetic variations within human TLRs have been reported to be associated with rheumatoid arthritis (RA). This study was conducted to investigate correlation between SNP of downstream mononucleotide in signal transduction of Toll-like receptors and predisposing genes of RA. There was obviously correlative between single nucleotide polymorphism and predisposing genes of RA. G-type of IL-1RAP rs766442 may be protecting genes of RA, while T-type alleles of IL-6R rs11265618 and IL-1RAP rs766442 may be susceptible genes of RA. In conclusion, the studies on the nucleis acid polymorphism in TLRs signal pathway contribute to disclose genesβ influence on the attack mechanism of RA, early diagnosis and treatment of RA.Π’ΠΎΠ»Π»-ΠΏΠΎΠ΄ΠΎΠ±Π½ΡΠ΅ ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΡ (TLRs) ΠΈΠ³ΡΠ°ΡΡ Π²Π°ΠΆΠ½ΡΡ ΡΠΎΠ»Ρ Π² ΠΈΠ½Π΄ΡΠΊΡΠΈΠΈ ΠΈ ΡΠ΅Π³ΡΠ»ΡΡΠΈΠΈ Π²ΡΠΎΠΆΠ΄Π΅Π½Π½ΠΎΠΉ ΠΈΠΌΠΌΡΠ½Π½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ ΠΈΠ»ΠΈ Π°Π΄Π°ΠΏΡΠΈΠ²Π½ΡΡ
ΠΈΠΌΠΌΡΠ½Π½ΡΡ
ΠΎΡΠ²Π΅ΡΠ°Ρ
. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΡΡΠΎ Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠ°Ρ ΠΈΠ·ΠΌΠ΅Π½ΡΠΈΠ²ΠΎΡΡΡ TLRs ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° ΡΠ²ΡΠ·Π°Π½Π° Ρ ΡΠ΅Π²ΠΌΠ°ΡΠΎΠΈΠ΄Π½ΡΠΌ Π°ΡΡΡΠΈΡΠΎΠΌ (Π Π). Π¦Π΅Π»ΡΡ Π½Π°ΡΡΠΎΡΡΠ΅ΠΉ ΡΠ°Π±ΠΎΡΡ Π±ΡΠ»ΠΎ ΠΈΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΠΉ ΠΌΠ΅ΠΆΠ΄Ρ ΠΎΠ΄Π½ΠΎΠ½ΡΠΊΠ»Π΅ΠΎΡΠΈΠ΄Π½ΡΠΌ ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠΎΠΌ Π² ΡΠΈΠ³Π½Π°Π»ΡΠ½ΠΎΠΉ ΡΡΠ°Π½ΡΠ΄ΡΠΊΡΠΈΠΈ TLRs ΠΈ Π³Π΅Π½Π°ΠΌΠΈ ΠΏΡΠ΅Π΄ΡΠ°ΡΠΏΠΎΠ»ΠΎΠΆΠ΅Π½Π½ΠΎΡΡΠΈ ΠΊ Π Π. G-ΡΠΈΠΏ IL-1RAP rs766442 ΠΌΠΎΠ³ΡΡ Π±ΡΡΡ Π³Π΅Π½Π°ΠΌΠΈ, ΠΏΡΠ΅Π΄ΠΎΡ
ΡΠ°Π½ΡΡΡΠΈΠΌΠΈ ΠΎΡ Π Π, Π² ΡΠΎ Π²ΡΠ΅ΠΌΡ ΠΊΠ°ΠΊ Π°Π»Π»Π΅Π»ΠΈ T-ΡΠΈΠΏΠ° IL-6R rs11265618 ΠΈ IL-1RAP rs766442 ΠΌΠΎΠ³ΡΡ Π±ΡΡΡ Π³Π΅Π½Π°ΠΌΠΈ ΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΠΊ Π Π. ΠΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠ° Π½ΡΠΊΠ»Π΅ΠΈΠ½ΠΎΠ²ΡΡ
ΠΊΠΈΡΠ»ΠΎΡ Π² ΡΠΈΠ³Π½Π°Π»ΡΠ½ΠΎΠΌ ΠΏΡΡΠΈ TLRs ΠΌΠΎΠΆΠ΅Ρ Π²Π½Π΅ΡΡΠΈ Π²ΠΊΠ»Π°Π΄ Π² Π²ΡΡΠ²Π»Π΅Π½ΠΈΠ΅ ΡΡΠ°ΡΡΠΈΡ Π³Π΅Π½ΠΎΠ² Π² ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΠ°Ρ
ΠΏΡΠΈΡΡΡΠΏΠΎΠ² Π Π, ΡΠ°Π½Π½ΡΡ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΡ ΠΈ Π»Π΅ΡΠ΅Π½ΠΈΠ΅ Π Π.The study was supported by Shandong Province young scientist in incentive fund (Grant β 2006BS03018) and National Natural Science Foundation of China (Grant β 30801025)
The effect of applied electric field on pulsed radio frequency and pulsed direct current plasma jet array
Here we compare the plasma plume propagation characteristics of a 3-channel pulsed RF plasma jet array and those of the same device operated by a pulsed dc source. For the pulsed-RF jet array, numerous long life time ions and metastables accumulated in the plasma channel make the plasma plume respond quickly to applied electric field. Its structure similar as βplasma bulletβ is an anode glow indeed. For the pulsed dcplasma jet array, the strong electric field in the vicinity of the tube is the reason for the growing plasma bullet in the launching period. The repulsive forces between the growing plasma bullets result in the divergence of the pulsed dcplasma jet array. Finally, the comparison of 309βnm and 777βnm emissions between these two jet arrays suggests the high chemical activity of pulsed RF plasma jet array
Combined constraints on modified Chaplygin gas model from cosmological observed data: Markov Chain Monte Carlo approach
We use the Markov Chain Monte Carlo method to investigate a global
constraints on the modified Chaplygin gas (MCG) model as the unification of
dark matter and dark energy from the latest observational data: the Union2
dataset of type supernovae Ia (SNIa), the observational Hubble data (OHD), the
cluster X-ray gas mass fraction, the baryon acoustic oscillation (BAO), and the
cosmic microwave background (CMB) data. In a flat universe, the constraint
results for MCG model are,
()
,
()
,
()
,
()
, and ()
.Comment: 12 pages, 1figur
Generalized Holographic Dark Energy Model
In this paper, the model of holographic Chaplygin gas has been extended to
two general cases: first is the case of modified variable Chaplygin gas and
secondly of the viscous generalized Chaplygin gas. The dynamics of the model
are expressed by the use of scalar fields and the scalar potentials.Comment: 12 pages, to appear in Eur. Phys. J.
Does accelerating universe indicates Brans-Dicke theory
The evolution of universe in Brans-Dicke (BD) theory is discussed in this
paper.
Considering a parameterized scenario for BD scalar field
which plays the role of gravitational "constant" ,
we apply the Markov Chain Monte Carlo method to investigate a global
constraints on BD theory with a self-interacting potential according to the
current observational data: Union2 dataset of type supernovae Ia (SNIa),
high-redshift Gamma-Ray Bursts (GRBs) data, observational Hubble data (OHD),
the cluster X-ray gas mass fraction, the baryon acoustic oscillation (BAO), and
the cosmic microwave background (CMB) data. It is shown that an expanded
universe from deceleration to acceleration is given in this theory, and the
constraint results of dimensionless matter density and parameter
are, and
which is consistent with the
result of current experiment exploration, . In
addition, we use the geometrical diagnostic method, jerk parameter , to
distinguish the BD theory and cosmological constant model in Einstein's theory
of general relativity.Comment: 16 pages, 3 figure
Measurements of the observed cross sections for exclusive light hadrons containing at , 3.650 and 3.6648 GeV
By analyzing the data sets of 17.3, 6.5 and 1.0 pb taken,
respectively, at , 3.650 and 3.6648 GeV with the BES-II
detector at the BEPC collider, we measure the observed cross sections for
, , ,
and at the three energy
points. Based on these cross sections we set the upper limits on the observed
cross sections and the branching fractions for decay into these
final states at 90% C.L..Comment: 7 pages, 2 figure
Partial wave analysis of J/\psi \to \gamma \phi \phi
Using events collected in the BESII detector, the
radiative decay is
studied. The invariant mass distribution exhibits a near-threshold
enhancement that peaks around 2.24 GeV/.
A partial wave analysis shows that the structure is dominated by a
state () with a mass of
GeV/ and a width of GeV/. The
product branching fraction is: .Comment: 11 pages, 4 figures. corrected proof for journa
Direct Measurements of Absolute Branching Fractions for D0 and D+ Inclusive Semimuonic Decays
By analyzing about 33 data sample collected at and around 3.773
GeV with the BES-II detector at the BEPC collider, we directly measure the
branching fractions for the neutral and charged inclusive semimuonic decays
to be and , and determine the ratio of the two branching
fractions to be
- β¦